Journal article
Cognitive behavioral markers of neurodevelopmental trajectories in rodents
KHC Choy, JK Luo, CMJ Wannan, L Laskaris, A Merritt, WT Syeda, PM Sexton, A Christopoulos, C Pantelis, J Nithianantharajah
Translational Psychiatry | SPRINGERNATURE | Published : 2021
Abstract
Between adolescence and adulthood, the brain critically undergoes maturation and refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also represents a vulnerable period for the onset of symptoms in neurodevelopmental psychiatric disorders. Despite the wide use of rodent models to unravel neurobiological mechanisms underlying neurodevelopmental disorders, there is a surprising paucity of rigorous studies focusing on normal cognitive-developmental trajectories in such models. Here, we sought to behaviorally capture maturational changes in cognitive trajectories during adolescence and into adulthood in male and female mice using distinct behavioral paradigms...
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council Program Grant (1150083) to PMS, AC, and CP, and a Wellcome Trust Collaboration Grant (201529/Z/16/Z) to AC and PMS. PMS was supported by a Senior Principal Research Fellowship (1154434) from the National Health and Medical Research Council. CP was supported by a Senior Principal Research Fellowship (1105825) and a L3 Investigator Grant (1196508) from the National Health and Medical Research Council. JN was supported by an Australian Research Council Future Fellowship (140101327) and National Health and Medical Research Council Project Grant (1163504).